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Interleukin 2 mRNA induction in human lymphocytes: Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Structure of the human interleukin 2 gene. The t 14;18 chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains.

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Please review our privacy policy. A probe derived from this sequence detected a 1.

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Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia. N Engl J Med.

A new method for predicting signal sequence cleavage sites. For this reason, the novel gene was termed BCM for B cell maturation.

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Two distinct loci on the short arm of chromosome 16 are involved in myeloid leukemia. Chromosome aberrations and cancer.

Cloning and 7586 of the human interleukin 2 chromosomal gene. DNA sequencing with chain-terminating inhibitors. Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. A t 4;16 q26;p Human proto-oncogene c-mos maps to 8q This article has been cited by other articles in PMC.

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Differentiation of thymocytes in fetal organ culture: A unique cytogenetic-clinicopathological association. Open in a separate window. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis.

Three clones bccm isolated, which consisted, from 5′ to 3′, of the three first exons of the interleukin 2 gene followed by a 16p13 in-frame sequence encoding amino acids. Our data indicate that BCM is a new gene whose expression coincides with B cell terminal maturation.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Bmc simple method for displaying the hydropathic character of a protein. Predicting the orientation of eukaryotic membrane-spanning proteins.

Support Center Support Center. Genome instability in a region of human DNA enriched in Alu repeat sequences.

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. The detection and classification of membrane-spanning proteins. RNA molecular weight bdm by gel electrophoresis under denaturing conditions, a critical reexamination.

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A new specific chromosomal rearrangement, t 8;16 p11;p13in acute monocytic leukaemia. A cDNA library of tumour cells was screened with an interleukin 2 gene-specific probe. The open reading frame of BCM normal cDNA predicted a amino acid bmc with a single transmembrane domain which had no homology with any protein sequence stored in data banks. Human interleukin 2 gene is located on chromosome 4. Substrate specificity of protein kinase C.

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Leukemia and the disruption of normal hematopoiesis.

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